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The preliminary study on differentially expressed genes in ovarian cancer
Author(s): 
Pages: 221-224
Year: Issue:  4
Journal: CHINESE JOURNAL OF PRACTICAL GYNECOLOGY AND OBSTETRICS

Keyword:  卵巢癌基因表达cDNA芯片;
Abstract: 目的通过研究人卵巢癌组织和正常卵巢组织中差异表达的基因,筛选出卵巢癌相关基因以用于早期诊断和治疗.方法以cDNA基因表达谱芯片分析研究卵巢癌组织样本和正常卵巢组织的基因表达谱,计算机分析后比较两种组织中差异表达的基因.结果共筛选出差异表达的基因178条,表达上调基因有40条,下调基因138条,有显著表达差异的基因54条,涉及到11大类基因.结论卵巢癌同其它恶性肿瘤一样,是多种基因结构和功能改变的结果,有关卵巢癌特异性相关基因及其作用尚有待进一步研究.
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