Observation of serum insulin resistance index and sex hormone binding globulin level in patients with recurrent spontaneous abortion in early pregnancy
Author(s): Shen Juanjuan, Cai Juejin, Yan Honglin
Pages: 120-122
Year: 2016 Issue: 1
Journal: China Medicine
Keyword: Recurrent spontaneous abortion; Sex hormone binding globulin; Insulin resistance; Pregnancy;
Abstract: Objective To explore the serum insulin resistance index and sex hormone binding globulin (SHBG) level in patients with recurrent spontaneous abortion (RSA) in early pregnancy.Methods Totally 87 pregnant women in early pregnancy (8-10 weeks) with recurrent abortion history from March 2012 to June 2014 were selected as observation group;80 pregnant women in early pregnancy (8-10 weeks) without adverse pregnancy history were as control group.The age, height, weight, blood pressure, gravidity and parity were recorded;the SHBG, fasting blood glucose(FBG), fasting insulin(FINS), HOMA-IR, estradiol, testosterone and dehydroepiandrosterone sulfate(DHEAS) level were compared between the two groups.Results The diastolic blood pressure, gestational weeks, estradiol and testosterone were not statistically different between the two groups (P ＞0.05);the body mass index, systolic blood pressure, gravidity and abortion times were significantly different between observation group and control group [(24.1 ±1.2) kg/m2 vs (22.1 ±1.3) kg/m2, (118 ±10) mmHg vs (112±9) mmHg, (3.1±0.8) timesvs (1.8±0.6) times, (2.5±0.5) times vs (0.0±0.0) times] (P＜ 0.05).Compared with those in control group, the SHBG was significantly lower, the levels of FBG, FINS,HOMA-IR and DHEAS were significantly higher in observation group [(204 ± 25) mmol/L vs (251 ± 30) mmol/L,(4.8±0.6) mmol/L vs (4.4 ±0.4) mmol/L, (13.6±2.5) mIU/L vs (10.3 ±2.5) mIU/L, (2.9 ±0.7) vs (2.2 ± 0.5), (4.6 ± 0.5) μmol/L vs (4.2 ± 0.4) μmol/L] (P ＜ 0.05).Multi factor Logistic regression analysis showed that the possible determinants of RSA included body mass index [odds ratio (OR) =2.057, 95％ confidence interval (CI) : 1.671-96.829], sex hormone binding globulin (OR =1.756,95％ CI: 0.845-1.966) and DHEAS (OR =1.662,95％ CI:0.013-2.057).Conclusion The SHBG level decreases significantly in RSA patients in early pregnancy, resulting in rise of androgen levels and HOMA-IR, which may be a cause of RSA.
Pages: 120-122
Year: 2016 Issue: 1
Journal: China Medicine
Keyword: Recurrent spontaneous abortion; Sex hormone binding globulin; Insulin resistance; Pregnancy;
Abstract: Objective To explore the serum insulin resistance index and sex hormone binding globulin (SHBG) level in patients with recurrent spontaneous abortion (RSA) in early pregnancy.Methods Totally 87 pregnant women in early pregnancy (8-10 weeks) with recurrent abortion history from March 2012 to June 2014 were selected as observation group;80 pregnant women in early pregnancy (8-10 weeks) without adverse pregnancy history were as control group.The age, height, weight, blood pressure, gravidity and parity were recorded;the SHBG, fasting blood glucose(FBG), fasting insulin(FINS), HOMA-IR, estradiol, testosterone and dehydroepiandrosterone sulfate(DHEAS) level were compared between the two groups.Results The diastolic blood pressure, gestational weeks, estradiol and testosterone were not statistically different between the two groups (P ＞0.05);the body mass index, systolic blood pressure, gravidity and abortion times were significantly different between observation group and control group [(24.1 ±1.2) kg/m2 vs (22.1 ±1.3) kg/m2, (118 ±10) mmHg vs (112±9) mmHg, (3.1±0.8) timesvs (1.8±0.6) times, (2.5±0.5) times vs (0.0±0.0) times] (P＜ 0.05).Compared with those in control group, the SHBG was significantly lower, the levels of FBG, FINS,HOMA-IR and DHEAS were significantly higher in observation group [(204 ± 25) mmol/L vs (251 ± 30) mmol/L,(4.8±0.6) mmol/L vs (4.4 ±0.4) mmol/L, (13.6±2.5) mIU/L vs (10.3 ±2.5) mIU/L, (2.9 ±0.7) vs (2.2 ± 0.5), (4.6 ± 0.5) μmol/L vs (4.2 ± 0.4) μmol/L] (P ＜ 0.05).Multi factor Logistic regression analysis showed that the possible determinants of RSA included body mass index [odds ratio (OR) =2.057, 95％ confidence interval (CI) : 1.671-96.829], sex hormone binding globulin (OR =1.756,95％ CI: 0.845-1.966) and DHEAS (OR =1.662,95％ CI:0.013-2.057).Conclusion The SHBG level decreases significantly in RSA patients in early pregnancy, resulting in rise of androgen levels and HOMA-IR, which may be a cause of RSA.
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