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Preparation technique of drug-loaded microsphere by using poly lactic-co-glycolic acid
Author(s): HAN Fei, HU Yi-he, WANG Long, Department of Orthopedics, Xiangya Hospital of Central South University, Xinjiang Medical University
Pages: 92-
97
Year: 2016
Issue:
1
Journal: Chinese Journal of Medical Physics
Keyword: poly lactic-co-glycolic acid; drug-loaded microsphere; preparation; review;
Abstract: As a well biocompatible and biodegradable polymer, poly lactic-co-glycolic acid(PLGA) is very important in the biomedical field. The measures for preparing microsphere by using PLGA includes emulsion- solvent evaporation, phase separation, salting-out method, spray drying method, membrane emulsification, nanoprecipitation, supercritical fluid technology and so on. The principle, advantage and disadvantage, and research progress of mentioned techniques were summarized by analyzing domestic and foreign literatures.
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