Author(s): SUN Hongxia, CHEN Jianguang, Pharmaceutical College, Beihua University
Pages: 203-207
Year: 2016 Issue:  1
Journal: Food Science
Keyword:  schisandrin B; myocardial ischemia/reperfusion injury; oxygen free radicals release;
Abstract: Objective: To investigate the protective effect of schisandrin B(Sch B) on myocardial ischemia/reperfusion injury(MI/RI) and its underlying mechanism so as to provide theoretical basis for new drug development of traditional Chinese medicine(TCM) with defined activity and high efficiency against myocardial ischemia. Methods: Totally 60 male Wistar rats were randomly divided into six groups: control group, reperfusion injury(MI/RI) group, Sch B 20, 40 and 80 mg/(kg·d) dose groups and positive control drug metoprolol group(MET, 2.5 mg/(kg·d)). Drug intragastric(ig) administration was continued for three weeks before ischemia-reperfusion injury. General heart change and myocardial pathological change were observed, Evans blue and NBT staining was conducted to determine infarction area, and changes in serum enzymes and cytokines and cardiac function were measured at the end of the experiment. Results: Sch B could significantly alleviate heart damage induced by MI/RI, reduce the infarction area, elevate SOD and NO levels in serum, reduce MDA, CK-MB and LDH contents, improve myocardial function. Conclusion: Sch B has certain protective effects against myocardial ischemia-reperfusion injury in rats, and its mechanism may be related to reducing oxygen free radical release and protecting ischemic myocardium from MI/RI.