Prenatal screening and diagnosis of thalassemia in 5 306 couples in Huangpu District of Guangzhou city
Author(s): LI Hua, HE Xuxia, Population & family planning service center of Guangzhou Huangpu District
Pages: 37-39
Year: 2016 Issue: 1
Journal: Chinese Journal of Clinical Obstetrics and Gynecology
Keyword: thalassemia; prenatal screening; prenatal diagnosis; α-thalassemia; β-thalassemia;
Abstract: Objective To screening the ocurrence of thalassemia in Huangpu area,Guangzhou,thus to investigate the gene carrier rate of thalassemia and its types,so as to provide guidance for the prevention and management of thalassemia.Methods 5 306 couples who participated the project of birth defects in our district from 2008 January to 2012 December received Mediterranean anemia screening examination.Those with positive result(one or both of the coupls)underwent further thalassemia gene examination and prenatal diagnosis was suggested for those carrying the same type of thalassemia gene.Results Thalassemia gene carriers was detected in 1 338 people,among them 801 were simpleα-thalassemia carriers with the detection rate of 7.55%,and 498 were simpleβ-thalassemia with the detection rate of 4.69%,39 people wasα-compositeβ-thalassemia heterozygotes and the detect rate was0.37%.48 couples were thalassemia high-risk through prenatal diagnosis,10 of them confirmed with thalassemia and underwent abortion.Conclusions The incidence of A Mediterranean thalassemia of Huangpu District in Guangdong was lower than other regions,but the incidence ofβ-thalassemia was high.The accurate detection ofα-complexβ-thalassemiang heterozygotes is important in prenatal and postnatal care.
Pages: 37-39
Year: 2016 Issue: 1
Journal: Chinese Journal of Clinical Obstetrics and Gynecology
Keyword: thalassemia; prenatal screening; prenatal diagnosis; α-thalassemia; β-thalassemia;
Abstract: Objective To screening the ocurrence of thalassemia in Huangpu area,Guangzhou,thus to investigate the gene carrier rate of thalassemia and its types,so as to provide guidance for the prevention and management of thalassemia.Methods 5 306 couples who participated the project of birth defects in our district from 2008 January to 2012 December received Mediterranean anemia screening examination.Those with positive result(one or both of the coupls)underwent further thalassemia gene examination and prenatal diagnosis was suggested for those carrying the same type of thalassemia gene.Results Thalassemia gene carriers was detected in 1 338 people,among them 801 were simpleα-thalassemia carriers with the detection rate of 7.55%,and 498 were simpleβ-thalassemia with the detection rate of 4.69%,39 people wasα-compositeβ-thalassemia heterozygotes and the detect rate was0.37%.48 couples were thalassemia high-risk through prenatal diagnosis,10 of them confirmed with thalassemia and underwent abortion.Conclusions The incidence of A Mediterranean thalassemia of Huangpu District in Guangdong was lower than other regions,but the incidence ofβ-thalassemia was high.The accurate detection ofα-complexβ-thalassemiang heterozygotes is important in prenatal and postnatal care.
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