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Mitochondrial Dysfunction of Diabetic Cardiomyopathy
Author(s): YANG Mo
Pages: 731-
734
Year: 2015
Issue:
6
Journal: Advances in Cardiovascular Diseases
Keyword: 糖尿病心肌病; 线粒体; 氧化应激; 自噬;
Abstract: 糖尿病是一种代谢性疾病,是心血管疾病的独立危险因素.糖尿病心肌病是独立于冠状动脉疾病和高血压的糖尿病并发症之一,是一种多因素所致的复杂疾病,可导致较高的发病率及病死率.线粒体占心肌细胞中体积的35%~40%,心肌活动所需95%的ATP均由线粒体产生.当线粒体受损时,心脏功能可能随之出现异常.现对线粒体功能异常在糖尿病心肌病中作用机制的研究进展进行综述.
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