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Clinical observation of calcitriol combined with cinacalcet in the treatment of hemodialysis patients with secondary hyperparathyroidism
Author(s): 
Pages: 1451-1454
Year: Issue:  12
Journal: World Phytomedicines

Keyword:  Calcitriol Soft CapsulesCinacalcet Hydrochloride Tabletssecondary hyperparathyroidismhemodialysis;
Abstract: Objective To observe the clinical effect of calcitriol combined with cinacalcet in the treatment of hemodialysis patients with secondary hyperparathyroidism. Methods Hemodialysis patients(100 cases) with secondary hyperparathyroidism in Tianjin First Center Hospital from January 2008 to December 2014 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were po administered with Cinacalcet Hydrochloride Tablets, and the initial dosage was 25 mg/d. The dosage was adjusted according to the patient tolerance, once every 2 — 4 weeks, and the maximum dosage was 75 mg/d. The patients in treatment group were po administered with Calcitriol Soft Capsules on the basis of the control group, and the initial dosage was 0.25 μg/d, three times weekly. The frequency was no more than once every two days, and the dosage was adjusted once every 2 — 4 weeks. The patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the changes of Scr, BUN, KT/V, Ca, P, ALP, i PTH and volume of parathyroid gland in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.0% and 94.0%, respectively, and there were differences between two groups(P < 0.05). After treatment, BUN, SCr, and Kt/V in two groups had no significant difference compared before treatment. Ca in two groups was significantly increased, P, ALP, i PTH, and volume of parathyroid gland in two groups were significantly reduced, and the difference was statistically significant in the same group(P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). The incidence of adverse reactions in the control and treatment groups were 18.0% and 8.0%, respectively, and there were differences between two groups(P < 0.05). Conclusion Calcitriol combined with cinacalcet has clinical curative effect in the treatment of hemodialysis patients with secondary hyperparathyroidism, and can reduce parathyroid hormone and parathyroid gland volume, also can reduce the incidence of adverse reactions, which has a certain clinical application value.
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