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Clinical observation of Xingnaojing Injection combined with fibrinolysin in treatment of acute cerebral infarction
Author(s): 
Pages: 1477-1481
Year: Issue:  12
Journal: World Phytomedicines

Keyword:  Xingnaojing InjectionFibrinogenase for injectionacute cerebral infarction;
Abstract: Objective To observe the clinical effect of Xingnaojing Injection combined with fibrinolysin in treatment of acute cerebral infarction. Methods Patients(200 cases) with acute cerebral infarction in Chongqing Banan District Second People’s Hospital from July 2012 to January 2015 were randomly divided into control and treatment groups, and each group had 100 cases. The patients in the control group were iv administered with Fibrinogenase for injection on the basis of conventional treatment, 100 U Fibrinogenase for injection added into 5% Glucose Injection 250 m L, once daily. The patients in the treatment group were iv administered with Xingnaojing Injection on the basis of the control group, 20 m L/time, once daily. The patients in two groups were treated for 12 weeks. After treatment, the efficacy was evaluated, and the changes of NIHSS scores, ADL scores, hemodynamic indexes high blood viscosity(HBV), low blood viscosity(LBV), hematocrit(HCT), plasma viscosity(SV), fibrinogen(FIB), blood sedimentation(ESR), and platelet aggregation rate(PAR) in two groups before and after treatment were compared. Results The clinical efficacy of patients with mild and moderately severe acute cerebral infarction in treatment group was higher than that in control group with significant difference(P < 0.05). And the efficacy of patients with mild acute cerebral infarction was higher than that of patients with moderately severe acute cerebral infarction in same group with significant difference(P < 0.05). After treatment, NIHSS and ADL scores of patients with mild and moderately severe acute cerebral infarction were improved compared with those of same group before treatment, and there were significant difference(P < 0.05). After treatment, NIHSS and ADL scores of patients with mild and moderately severe acute cerebral infarction in treatment group were improved more than those in control group with significant difference(P < 0.05). HBV, LBV, HCT, FIB, SV, and PAR of two groups were improved more than those in same group after treatment with significant difference(P < 0.05). HBV, HCT, FIB, SV, ESR, and PAR in treatment group were improved more than those in control group after treatment with significant difference(P < 0.05). Conclusion Xingnaojing Injection combined with fibrinolysin has clinical curative effect in treatment of acute cerebral infarction, and can improve nerve function and quality of life, significantly improve hemodynamic indexes, which has a certain clinical application value.
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