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Clinical observation of Xueshuantong Injection combined with rivaroxaban in treatment of lower limb deep vein thrombus after hip replacement
Author(s): 
Pages: 1490-1493
Year: Issue:  12
Journal: World Phytomedicines

Keyword:  Xueshuantong InjectionRivaroxaban Tabletship replacementlower limb deep vein thrombusvenous blood flow velocityAPTTPTTTFIB;
Abstract: Objective To explore the clinical effect of Xueshuantong Injection combined with rivaroxaban in treatment of lower limb deep vein thrombus after hip replacement. Methods Patients(78 cases) with lower limb deep vein thrombus after hip replacement in Yan’an University Affiliated Hospital from November 2011 to November 2014 were enrolled in this study. According to the different treatment plan, patients were divided into treatment group(39 cases) and control group(39 cases). The patients in the control group were po administered with Rivaroxaban Tablets, 1 tablet/time, once daily. The patients in the treatment group were iv administered with Xueshuantong Injection on the basis of control group, 5 m L Xueshuantong Injection added into 250 m L 0.9% normal saline, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacy were evaluated, and the changes of D-dimer, lower limb diameter difference above and below the knee, venous blood flow velocity, APTT, PT, TT, and FIB in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.62% and 97.44%, respectively, and there were differences between two groups(P < 0.05). After treatment, D-dimer, lower limb diameter difference above and below the knee, and FIB in two groups were significantly decreased, venous blood flow velocity, APTT, PT, and TT were significantly increased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Xueshuantong Injection combined with rivaroxaban has clinical curative effect in treatment of lower limb deep vein thrombus after hip replacement, and can significantly improve the blood coagulation state, which has a certain clinical application value.
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