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Clinical observation of amlodipine combined with magnesium sulfate in treatment of gestational hypertension
Author(s): 
Pages: 1511-1514
Year: Issue:  12
Journal: World Phytomedicines

Keyword:  Amlodipine Besylate TabletsMagnesium Sulfate Injectiongestational hypertension;
Abstract: Objective To observe the clinical effect of amlodipine combined with magnesium sulfate in treatment of gestational hypertension. Methods Patients(100 cases) with gestational hypertension in the Second Hospital of Longyan from April 2012 to June 2015 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were iv administered with Magnesium Sulfate Injection, 20 m L Magnesium Sulfate Injection added into 5% glucose solution 100 m L, which finished within 0.5 h. And then they were iv administered with Magnesium Sulfate Injection 60 m L added into 5% glucose solution 1000 m L in 9 h. The patients in treatment group were po administered with Amlodipine Besylate Tablets, 10 mg/time, once daily. When blood pressure descended to the target, patients in two groups were accepted continuous treatment until the end of the pregnancy. After treatment, the efficacy and pregnancy outcomes were evaluated, and the changes of blood pressure in two groups were compared before and after treatment. Results After treatment, the efficacies in the control and treatment groups were 68.0% and 90.0%, respectively, and there were differences between two groups(P < 0.05). After treatment, systolic and diastolic blood pressures in two groups were significantly reduced, and the difference was statistically significant in the same group(P < 0.05). These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups(P < 0.05). The incidence of postpartum hemorrhage, premature labor, placental abruption, neonatal respiratory distress, and neonatal death were lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Amlodipine combined with magnesium sulfate has clinical curative effect in treatment of gestational hypertension, and can significantly reduce the blood pressure, also can improve the pregnancy outcome, which has a certain clinical application value.
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