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Clinical observation of Huangqi Granules combined with insulin aspart in treatment of gestational diabetes
Author(s): 
Pages: 1519-1523
Year: Issue:  12
Journal: World Phytomedicines

Keyword:  Huangqi GranulesInsulin Aspart Injectionblood glucoseblood lipid;
Abstract: Objective To investigate the clinical effects of Huangqi Granules combined with insulin aspart in treatment of gestational diabetes. Methods Puerperae(100 cases) with gestational diabetes in Chengdu Tianfu New District People’s Hospital from February 2013 to February 2015 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were sc administered with Insulin Aspart Injection on the basis of general treatment, 0.5—1.0 U/kg, 2/3 dosage when having dinner, and the remaining 1/3 was basal insulin. The patients in the treatment group were po administered with Huangqi Granules on the basis of the control group, 15 g/d, twice daily. The patients in two groups were treated for 4 weeks as a course. After treatment, the efficacy, urinary protein, urea nitrogen, serum creatinine and haemoglobin(Hb A1c), blood glucose and blood lipid indicators total cholesterol(TC) and triacylglycerol(TG), recovering time of blood glucose, insulin dose, and blood sugar occurrence rate, and physiological status of puerperae and infants after delivery. Results The clinical efficacy in treatment group(90.00%) was higher than that in control group(82.00%) with significant difference(P < 0.05). After treatment, urinary protein, urea nitrogen, serum creatinine, and Hb A1 c of two groups were lower than those before treatment, and the difference was significant(P < 0.05). These observed indexes in treatment group were better than those in control group, with significant difference between two groups(P < 0.05). Fasting blood glucose and blood glucose after dinner for 2 h, and TC and TG in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). These observational indexes in treatment group were better than those in control group, with significant difference between two groups(P < 0.05). After treatment, recovering time of blood glucose, insulin dose, and blood sugar occurrence rate in treatment group were lower than those in control group, with significant difference between two groups(P < 0.05). Pregnant outcome indicators of puerperae and infants in treatment group were better than those in control group with significant difference(P < 0.05). Conclusion Huangqi Granules combined with insulin aspart has good effect in treatment of gestational diabetes, which has a certain clinical application value.
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