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Clinical observation of Zilongjin Tablets combined with docetaxel and nedpltin in treatment of locally advanced non small cell lung cancer
Author(s): 
Pages: 1506-1510
Year: Issue:  12
Journal: World Phytomedicines

Keyword:  Zilongjin TabletsDocetaxel InjectionNedaplatin for injectionnon small cell lung cancerquality of life;
Abstract: Objective To observe the clinical curative effect of Zilongjin Tablets combined with Docetaxel Injection and Nedaplatin for injection in treatment of locally advanced non small cell lung cancer. Methods Patients(78 cases) with locally advanced non small cell lung cancer in Department of Respiration and Critical Care Medicine of Tianjin Chest Hospital from February 2014 to July 2015 were randomly divided into control and treatment groups, and each group had 39 cases. The patients in the control group were iv administered with Docetaxel Injection 75 mg/m~2 in the first day, added into 0.9% normal saline 250 m L. And the control group was also iv administered with Nedaplatin for injection 80 mg/m~2 in the second day, added into 0.9% normal saline 500 m L. The patients in the treatment group were po administered with Zilongjin Tablets 2.6 g on the basis of the control group, three times daily. A course of treatment included 3 weeks, and the patients in two groups were treated for two courses. After treatment, the efficacy was evaluated, and quality of life, levels of T lymphocyte subsets, and side effects in two groups before and after treatment were compared. Results After treatment, the remission rates in the control and treatment groups were 15.4% and 20.5%, and the control rates were 84.6% and 92.3% respectively, and there was no difference between two groups. After treatment, scores of physical function, role function, social function, and general health in treatment group were significantly increased(P < 0.05), but scores of fatigue and shortness of breath were significantly decreased(P < 0.05). After treatment, scores of physical function, role function, social function, general health, fatigue, and shortness of breath in the treatment group were better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, levels of CD8 in the treatment group were obviously decreased, but CD4/CD8 was significantly increased, and the difference was statistically significant in the same group(P < 0.05, 0.01). These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups(P < 0.05). Nausea and vomiting and leucopenia in treatment group were better than those in the control group(P < 0.05). Conclusion Zilongjin Tablets combined with Docetaxel Injection and Nedaplatin for injection has a clinical curative effect in the treatment of locally advanced non small cell lung cancer, and can improve quality of life, improve body immunity, and reduce side effects, which has a certain clinical application value.
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