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Effect of TCDD on fish liver in Jian carp (Cyprinus carpio var.Jian)
Author(s): 
Pages: 1720-1724
Year: Issue:  10
Journal: Acta Agriculturae Zhejiangensis

Keyword:  2378-tetrachlorodibenzo-p-dioxin (TCDD)GOTGPTLDHGSH-PxGSTT-AOC;
Abstract: 研究2,3,7,8-四氯二苯并-p-二噁英(TCDD)对建鲤肝组织的影响.将建鲤随机分为5个处理组和1个空白对照组,每组30尾鱼.采用一次性腹腔注射染毒,处理组注射剂量分别为0.1,0.3,0.6,1.2,2.4 μg·kg-,空白组注射同体积二甲基亚砜(DMSO).分别于给药后24,48,72,96,120 h采集血液及肝组织,测定谷草转氨酶(GOT)、谷丙转氨酶(GPT)、乳酸脱氢酶(LDH)、谷胱甘肽过氧化物酶(GSH-Px)、谷胱甘肽S-转移酶(GST)活力和总抗氧化能力(T-AOC)的变化.结果表明:TCDD染毒72 h,各染毒组损伤程度较严重,GOT,LDH,GPT活性值显著升高(P<0.01或P<0.05),GST,GSH-Px,T-AOC活力显著降低(P<0.01或P<0.05).这说明TCDD急性染毒后可以造成建鲤肝组织的损伤,引起建鲤肝组织的氧化应激反应.
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