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Relationship between Serum MMP-9,hsCRP,IL-6and the Carotid Atherosclerosis Plaque in Patients Acute Cerebral Infarction
Author(s): 
Pages: 1765-1767
Year: Issue:  15
Journal: Research of Traditional Chinese Medicine

Keyword:  acute cerebral infarctioncarotid atherosclerosismatrix metalloproteinase-9high sensitive C-reactive proteininterleukin-6;
Abstract: Objective To investigate the relationship between serum matrix metalloproteinases-9(MMP-9)and high-sensitivity C-reactive protein(hsCRP),interleukin-6(IL-6)and carotid atherosclerosis(CAS)patients with acute cerebral infarction(ACI).Methods One hundred and twelve patients with ACI,according to the results of carotid artery Doppler ultrasound,were divided into CAS soft plaque group(n=31),hard plaque group(n=53)and no plaque group(n=28).Thirty healthy individuals were as controls.The levels of serum MMP-9,hsCRP and IL-6 were detected by-linked immunosorbent method.Results The levels of serum MMP-9,hsCRP,IL-6in ACI groups were higher than that in control group(P<0.01).The levels of serum MMP-9,hsCRP,IL-6 in CAS soft plaque group were higher than that in hard plaque group(n=53)and no plaque group(P<0.05).Conclusion MMP-9,hsCRP,IL-6 are closely related to the formation and stability of the CAS in patients with ACI,They may be clinical marker of soft unstable plaque,and to provide experimental basis for plaque stability evaluation,treatment monitoring and intervention.
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