Author(s): LI Yu-xiang, TU Ping, WANG Yang, Department of Dermatoloy, the First Hospital of Peking University
Pages: 584-587
Year: 2015 Issue:  9
Journal: Journal of Clinical Dermatology
Keyword:  mycosis fungoides; efficacy analysis;
Abstract: Objective: To analyze the efficacy of NB-UVB alone or in combination with interferon in treating stage Ⅰ and stage Ⅱ mycosis fungoides(MF). Method: Clinical data of 64 MF patients were retrospectively analyzed. All patients were clinically and pathologically diagnosed with MF, and treated with either a. NB-UVB, b. NB-UVB+interferon-alpha(IFN-α), or c. NB-UVB+IFN-α+methotrexate(MTX)+low dose of glucocorticoids+acitretin. Results: The 64 patients consisted of 15 cases of stage ⅠA, 33 cases of stage ⅠB, 10 cases of stage ⅡA and 6 cases of stage ⅡB. The effective rates in patients treated with methods a, b and c were 91.18%,86.67%, and 53.33%, respectively. Among stage ⅠA, ⅠB, and ⅡA patients,19 patients(32.76%) were completely relieved and 30 patients(51.72%) were partially relieved. The total effective rate was84.48%. Complete and partial relief were 1 each among stage ⅡB patients(total effective rate, 33.33%). Conclusion:Treatment with NB-UVB alone or NB-UVB combined with IFN-α is more effective for early stage MF than for stage ⅡB MF. IFN combined with MTX、glucocorticoids, and acitretin capsules displays some benefit for ⅡB.