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Relationship between serum homocysteine protease inhibitor, group protein B1 with high mobility rate and renal damage of patients with acute pancreatitis
Author(s): 
Pages: 2575-2577
Year: Issue:  10
Journal: Chinese Journal of Experimental Surgery

Keyword:  Acute pancreatitisSerum cystatinHigh mobility group protein B1Damage of renal function;
Abstract: Objective To explore the relationship between serum homocysteine (CyC) protease inhibitor, group protein B1 (HMGB1) with high mobility rate and renal damage of patientwith acute pancreatitis.MethodEighty-eighcaseof acute pancreatitiwere divided into pancreatinephropathy (NP) group (n =37) and acute pancreatiti(AP) group (n =51).Eighty-eighhealthy volunteerwere chosen athe control group (n =88).All subjectreceived examination of serum CyC, serum HMGB1,serum C-reactive protein (CRP), serum creatinine (SCr), 24 h creatinine clearance rate (CCr), tumonecrosifactoalph(TNF-alpha), interleukin-6 (IL-6) and otheindicatorwithin 2 dayafteadmission.The resultof the examinationwere recorded and compared.ResultIn AP group, Cywa(1.35 ±0.33) g/L, HMGB1 (5.53±1.52) μg/L, CRP (44.68 ±13.54) mg/L, SC(152.65 ± 21.67) μmol/L, TNF-o (3.44 ±0.51) ng/L and IL-6 (267.56 ±69.46) ng/L;in NP group, Cywa(2.89 ±0.41) g/L, HMGB1 (13.86 ±3.41) μg/L, CRP (89.54 ± 15.16) mg/L, SC(233.59 ± 54.63) μmol/L, TNF-α (3.44 ±0.51) ng/L, IL-6 (351.36 ±75.13) ng/L;and in control group,Cyswa(0.98 ±0.32) g/L, HMGB1 (1.70 ±0.49) μg/L, CRP (2.76 ±0.68) mg/L, SC(91.65 ± 22.53) μmol/L, TNF-α (1.35 ± 0.33) ng/L and IL-6 (116.59 ± 34.68) ng/L.The CyC, HMGB1, CRP, SCr, TNF-α and IL-6 were lowesin control group, followed by AP group and NP group (P <0.05).The CCin NP group [(55.13 ±5.69) ml/min] wasignificantly lowethan the othetwo group(P <0.05);(2) CyC, HMGB1 and SCwere all negatively correlated with damage of renal function.Conclusion The serum Cyand HMGB1 can be taken aimportanindicatorof renal function damage in patientwith acute pancreatitis.
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