Research Progress of Transcription Factors in Tendon Regeneration
Author(s): ZHAO Yun-long, QU Yan-long, WANG Qiang, MIAO Qing, LI Peng-wei, First Clinical College of Harbin Medical University
Pages: 5986-5988
Year: 2015 Issue: 30
Journal: Biomagnetism
Keyword: Tendon transcription factors; Scleraxis; Mohawk; Sox9; Egr1/2; Tendon regeneration;
Abstract: Tendons that connect muscles to bone are considered to be the targets of sports injuries. The currently unsatisfactory state of tendon repair is largely attributable to the limited understanding of basic tendon biology. A number of tendon lineage-related transcription factors have recently been discovered and proved to provide clues for the better understanding of the development of tendon.Scleraxis and Mohawk have been identified as critical transcription factors in tendon’s development and differentiation. Other transcription factors, such as Sox9 and Egr1/2 also have been reported to be involved in tendon’s development. However, the molecular mechanisms and the application of those transcription factors have not been clearly proved. This article reviews the distribution and function of the transcription factors and factors related to them to provide a biological basis, as well as to discuss the future directions of development for the treatment of tendon repairment.
Pages: 5986-5988
Year: 2015 Issue: 30
Journal: Biomagnetism
Keyword: Tendon transcription factors; Scleraxis; Mohawk; Sox9; Egr1/2; Tendon regeneration;
Abstract: Tendons that connect muscles to bone are considered to be the targets of sports injuries. The currently unsatisfactory state of tendon repair is largely attributable to the limited understanding of basic tendon biology. A number of tendon lineage-related transcription factors have recently been discovered and proved to provide clues for the better understanding of the development of tendon.Scleraxis and Mohawk have been identified as critical transcription factors in tendon’s development and differentiation. Other transcription factors, such as Sox9 and Egr1/2 also have been reported to be involved in tendon’s development. However, the molecular mechanisms and the application of those transcription factors have not been clearly proved. This article reviews the distribution and function of the transcription factors and factors related to them to provide a biological basis, as well as to discuss the future directions of development for the treatment of tendon repairment.
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