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Studies on the pathogenesis of Caprine parainfluenza virus type3 JS2013 strain on guinea pigs
Author(s): 
Pages: 1-5
Year: Issue:  9
Journal: Liaoning Journal of Animal Husbandry & Veterinary Medicine

Keyword:  CPIV3PathogenesisGuinea pigs;
Abstract: For further exploring about the pathogenic of CPIV3 strain JS2013, the guinea pigs as PIV3 susceptible animals were infected with the virus isolate to study on the virus replication and pathological injury in the experimental animal tissues. The noted clinical symptoms were sneezing, eye secretion and dyspnea in the infected guinea pigs at 2 days post-infection(PI).The virus replicated in the blood of the infected animals and could be positively detected from 3days PI and kept for 7 days PI. Macroscopic appearances of the lungs from infected guinea pigs were almost complete consolidation and swelling. The histopathologic examinations showed that alveoli septa thickening, disappearance of alveolar architecture and inflammatory cell infiltration were seen in the lungs of the diseased. The infected guinea pigs produced the special HI antibodies against CPIV3 in 5 days PI.
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