Vascular endothelial growth factor-nitric oxide axis and diabetic nephropathy
Author(s): Ren Huizhu, Zhou Saijun
Pages: 354-356
Year: 2015 Issue: 5
Journal: International JOurnal of Endocrinology and Metabolism
Keyword: Diabetic nephropathy; Vascular endothelial growth factor; Nitric oxide; Nitric oxide synthase; Oxidative stress;
Abstract: The coupling of vascular endothelial growth factor (VEGF) with nitric oxide (NO),known as the VEGF-NO axis,plays a critical role in maintaining normal glomerular endothelial cell function,its uncoupling involves in the occurrence and development of diabetic nephropathy.Reduction of endothelial nitric oxide synthase (eNOS) activity is likely to be the key mechanism of VEGF-NO axial decoupling in diabetic kidney.Obesity,hyperlipidemia,and oxidative stress may be main reasons of VEGF-NO axis uncoupling in diabetes kidney.Adiponectin,heme oxygenase-1 could obviously improve glomerular endothelial cell function of diabetic rat,reduce proteinuria via resisting oxidative stress to improve the function of the VEGF-NO axis.
Pages: 354-356
Year: 2015 Issue: 5
Journal: International JOurnal of Endocrinology and Metabolism
Keyword: Diabetic nephropathy; Vascular endothelial growth factor; Nitric oxide; Nitric oxide synthase; Oxidative stress;
Abstract: The coupling of vascular endothelial growth factor (VEGF) with nitric oxide (NO),known as the VEGF-NO axis,plays a critical role in maintaining normal glomerular endothelial cell function,its uncoupling involves in the occurrence and development of diabetic nephropathy.Reduction of endothelial nitric oxide synthase (eNOS) activity is likely to be the key mechanism of VEGF-NO axial decoupling in diabetic kidney.Obesity,hyperlipidemia,and oxidative stress may be main reasons of VEGF-NO axis uncoupling in diabetes kidney.Adiponectin,heme oxygenase-1 could obviously improve glomerular endothelial cell function of diabetic rat,reduce proteinuria via resisting oxidative stress to improve the function of the VEGF-NO axis.
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