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Diffusion tensor imaging evaluation of infratentorial fasciculi in multiple system atrophy
Author(s): 
Pages: 1312-1316
Year: Issue:  9
Journal: Chinese Journal of Medical Imaging Technology

Keyword:  Multiple system atrophyDiffusion magnetic resonance imaging;
Abstract: Objective To assess the diagnostic value of MR DTI parameters in infratentorial regions of patients with multiple system atrophy(MSA).Methods Conventional MRI and DTI were performed in 8clinically proved MSA patients(MSA group)and 10 normal controls(control group).For quantitative assessment,the ADC and FA values of the width of bilateral middle cerebellar peduncle(MCP),the anteroposterior diameter of pontine,inferior cerebellar peduncle(ICP),middle cerebellar peduncle(MCP),superior cerebellar peduncle(SCP),brainstem corticospinal tract(CST),cross fiber(CF),the medial lemniscus(ML),the white matter of cerebral were measured and statistically analyzed.Results Compared with the control group,the FA values of MSA group in bilateral ICP,MCP,SCP,right ML and bilateral cerebellum significantly deceased;and the ADC values of MSA group in the right side of ICP,bilateral MCP,bilateral SCP,CF,the left ML and bilateral cerebellum significantly increased.ADC and FA values of MCP were correlated with its degree of atrophy;and the ADC and FA values of CST,CF,ML were correlated with the atrophy of pontine.The ADC and FA values among controls,MSA cross sign negative and positive patients were statistically significant.Conclusion DTI can noninvasively evaluate the infratentorial lesions of MSA patients,and DTI is more sensitive than conventional MRI to discover abnormal structure.
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