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Real-time three-dimensional echocardiography for evaluation of right ventricular function in systemic lupus erythematosus patients with pulmonary hypertension
Author(s): 
Pages: 1331-1335
Year: Issue:  9
Journal: Chinese Journal of Medical Imaging Technology

Keyword:  Systemic lupus erythematosusEchocardiographythree-dimensionalHeart functionrightPulmonary arterial hypertension;
Abstract: Objective To evaluate right ventricular(RV)regional and global structural and functional abnormalities in patients with systemic lupus erythematosus(SLE)complicated with pulmonary arterial hypertension(PAH),and to analyze the relationship between echocardiographic parameters using the real-time three-dimensional echocardiography(RT-3DE)and routine echocardiography.Methods Sixty patients with SLE(without PAH subgroup,mild PAH subgroup,moderate to severe PAH subgroup)and twenty-eight healthy control subjects(control group)were included.Standard echocardiography was performed.RT-3DE with full-volume imaging was acquired for RV end diastolic volume(RVEDVI-3D),end systolic volume(RVESVI-3D)and ejection fraction(RVEF-3D).All data was compared using analysis of variance with post hoc correlation.Simple linear regression analysis was used for comparison of conventional echocardiographic parameters,RT-3DE RV volume and RVEF,and RV hemodynamic variables including pulmonary arterial systolic pressure(PASP),pulmonary vascular resistance(PVR).Results RV outflow tract diameter in patients with PAH was significantly larger than that in control group(all P<0.05).Right atria and RV was significantly larger in moderate to severe PAH subgroup than that in other groups(all P<0.05).The s,e/a,RVFAC significantly reduced,RV Tei index significantly higher in SLE patients than that in control group(all P<0.05).RVEDVI-3D,RVESVI-3Dand RVEF-3Dreduced obviously in moderate to severe PAH subgroup compared with other groups(all P<0.05).Regression analysis revealed a significant correlation between tricuspid annular plane systolic excursion(TAPSE),s,RVFAC,RVTei with PASP(all P<0.001).RVEF-3Dhad a positive correlation with TAPSE(P<0.001).PASP,PVR,RVTei and s had a weak relationship with RVEDVI-3Dand RVESVI-3D(P<0.001).Conclusion RT-3DE can be used to quantitatively,easily and accurately assess RV entire systolic function in patients with SLE.
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