Expressions and Significances of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Recep-tor B in Endometrial Carcinoma
Author(s): CHEN Xuna, YE Zhizhong
Pages: 1477-1479
Year: 2015 Issue: 8
Journal: Journal of Clinical Research
Keyword: Brain-Derived Neurotrophic Factor/ME; Receptor Protein-Tyrosine Kinases/ME; En-dometrial Neoplasms/PA; Immunohistochemistry;
Abstract: [Objective]To explore the expressions of brain-derived neurotrophic factor (BDNF)and tyro-sine kinase receptor B (TrkB)in endometrial carcinoma and analyze their clinical significances.[Methods]The expressions of BDNF and TrkB were detected by immunohistochemistry in normal endometrium (n = 22), hyperplasia endometrium (n =32)and endometrial carcinoma (n =62).And the relationship with their clini-copathological characteristics were analyzed.[Results]BDNF and TrkB were negatively or weakly positively expressed in normal endometrium while positively in hyperplasia endometrium and endometrial carcinoma.And statistically significant differences existed among three groups (P < 0.05 ).The expressions of BDNF and TrkB in endometrial carcinoma were significantly correlated with tumor cell differentiation,clinicopathologic staging,myometrial invasion and lymph node metastasis of endometrial carcinoma (P <0.05).[Conclusion]The interaction of BDNF with TrkB may play an important synergistic role in the occurrence and development of endometrial carcinoma.
Pages: 1477-1479
Year: 2015 Issue: 8
Journal: Journal of Clinical Research
Keyword: Brain-Derived Neurotrophic Factor/ME; Receptor Protein-Tyrosine Kinases/ME; En-dometrial Neoplasms/PA; Immunohistochemistry;
Abstract: [Objective]To explore the expressions of brain-derived neurotrophic factor (BDNF)and tyro-sine kinase receptor B (TrkB)in endometrial carcinoma and analyze their clinical significances.[Methods]The expressions of BDNF and TrkB were detected by immunohistochemistry in normal endometrium (n = 22), hyperplasia endometrium (n =32)and endometrial carcinoma (n =62).And the relationship with their clini-copathological characteristics were analyzed.[Results]BDNF and TrkB were negatively or weakly positively expressed in normal endometrium while positively in hyperplasia endometrium and endometrial carcinoma.And statistically significant differences existed among three groups (P < 0.05 ).The expressions of BDNF and TrkB in endometrial carcinoma were significantly correlated with tumor cell differentiation,clinicopathologic staging,myometrial invasion and lymph node metastasis of endometrial carcinoma (P <0.05).[Conclusion]The interaction of BDNF with TrkB may play an important synergistic role in the occurrence and development of endometrial carcinoma.
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