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Clinical observation of Compound Danshen Dripping Pills combined with cinepazide maleate in treatment of unstable angina
Author(s): 
Pages: 1079-1082
Year: Issue:  9
Journal: World Phytomedicines

Keyword:  Compound Danshen Dripping PillsCinepazide Maleate Injectionunstable anginaleft ventricular ejection fractionwhole blood viscosity;
Abstract: Objective To investigate the clinical efficacy of Compound Danshen Dripping Pills combined with cinepazide maleate in treatment of unstable angina.Methods Patients (120 cases) with unstable angina in Chengdu Military General Hospital from January 2014 to December 2014 were randomly divided into control and treatment groups, and each group had 60 cases. The patients in the control group were iv administered with Cinepazide Maleate Injection, 8 mL/time which was diluted in 10% glucose injection or physiological saline (500 mL), once daily with the drip speed of 100 mL/h. The patients in the treatment group werepo administered with Compound Danshen Dripping Pills, 10 pills/time, three times daily. The patients in two groups were treated for 12 weeks. After treatment, the efficacy was evaluated, the changes of cardiac function indexes including cardiac index (CI), cardiac output (CO), left ventricular ejection fraction (LVEF), left ventricular end systolic volume (LESV), and left ventricular end-diastolic volume (LEDV) and blood rheology indexes including whole blood viscosity, plasma viscosity, hematocrit, platelet aggregation rate, fibrinogen before and after treatment in the two groups were compared.Results After the treatment, the efficacies in the control and treatment groups were 73.33% and 91.67%, respectively, and there was difference between two groups (P < 0.05). After treatment, CI, CO, and LVEF in two groups were significantly increased, and LESV, LEDV, whole blood viscosity, plasma viscosity, hematocrit, platelet aggregation rate, and fibrinogen were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). The improved degree of those observation indicators in the treatment group was better than those in the control group, with significant difference between two groups (P < 0.05).Conclusion Compound Danshen Dripping Pills combined with cinepazide maleate has good clinical efficacy in treatment of unstable angina, and can improve cardiac function and hemodynamics, which has a certain clinical application value.
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