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Cyclin-dependent protein kinases 4/6 inhibitor:ribociclib
Pages: 1162-1166
Year: Issue:  9
Journal: World Phytomedicines

Keyword:  cyclin-dependent protein kinases 4/6breast cancermelanomanon-small cell lung cancer;
Abstract: The incidence of breast cancer is increasing year by year, and has become a major public health problem in the world. Cycle dependent protein kinase (CDK) 4/6 inhibitor can block cell cycle in G1 phase, which can inhibit tumor growth. Ribociclib is a highly specific protein kinases 4/6 inhibitor, which can inhibit D1/CDK4 and D3/CDK6 cell cycle, and has potential antitumor activity. The results of clinical trials indicate that ribociclib has clinical efficacy in treatment of breast cancer, melanoma, non-small cell lung cancer, teratoma, liposarcoma, and glioblastoma.
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