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Effect of Xiongzhi Dilong Decoction on NO,NOS and c GMP in Migraine Model with Wind-heat Syndrome
Author(s): 
Pages: 1165-1168
Year: Issue:  10
Journal: Research of Traditional Chinese Medicine

Keyword:  migrainewind-heat syndromeXiongzhi Dilong decoctionnitric oxidenitric oxide synthasecyclic guanosine monophosphate;
Abstract: Objective To study the effects of Xiongzhi Dilong decoction( XDD) on nitric oxide( NO) / NO synthase( NOS) / cyclic guanosine monophosphate( cGMP) in migraine with wind-heat syndrome. Methods The migraine model with wind-heat syndrome was established by combining exterior pathogen( hot wind) and GTN administration. The frequency of scratching head within 2 h was examined. The contents of plasma cyclic cGMP,NO and NOS were assayed by radioimmunoassay( RIA),nitrate reductase method and colorimetric method. Results The contents of plasma NOS,NO,and cGMP in migraine model were significantly higher than that in normal group and wind-heat group(P < 0. 01),and the contents of plasma NOS,NO and cGMP in migraine with wind-heat syndrome model persistently increased,which was significant difference compared to normal group(P < 0. 01),and was significant difference compared to migraine model group(P < 0. 05). The contents of plasma NOS,NO and cGMP in Chinese medicine treatment group were recovered,which was significant difference compared to migraine with wind-heat syndrome model and migraine model group(P <0. 05). Conclusion There is no significant effect on normal organism which sufferd from wind-heat,but there is significant effect on migraine model induced by nitroglycerin. The content of plasma NOS,NO and cGMP in migraine model which is invaded by wind and heat persistently increased. XDD can attenuate remarkably the contents of plasma NOS,NO and cGMP in migraine model with wind-heat syndrome.
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