Efficacy Study of Application of Estradiol and Midodrine Hydrochloride in Vaginal for Patients with Mild-to-moderate Stress Urinary Incontinence
Author(s): MENG Zhonglong, YAO Ruhe, LI Jianghui, LU Guohan, LAI Weizhan, CHAI Xiaoxia, Dept.of Surgery, Xinrongqi Hospital of Foshan Shunde Distinct
Pages: 999-1001
Year: 2015 Issue: 8
Journal: Evaluation and Analysis of Drug-Use in Hospital of China
Keyword: Stress urinary incontinence; Vaginal administration; Midodrine hydrochloride; TVT operation;
Abstract: OBJECTIVE: To probe into the clinic efficacy and safety of application of estradiol and midodrine hydrochloride in vaginal for patients with mild-to-moderate stress urinary incontinence. METHODS: 100 cases in Xinrongqi Hospital of Foshan Shunde Distinct from Jun. 2012 to Oct. 2015 were selected to be divided into the control group and observation group according to the random number table,with 50 cases in each group. The observation group received estradiol and midodrine hydrochloride in vaginal,the experimental group underwent TVT operation therapy. The clinic efficacy and self evaluation,the urine flow dynamic index before and after treatment,the adverse reactions,the improvement time of median average urinary incontinence and hospitalization costs and some other indexes were observed in two groups. RESULTS: After treatment,volume of urinary incontinence and self evaluation score in two groups both had an obvious improvement compared with before treatment,and the improvement in observation group was better than that in control group,with significant difference( P < 0. 05); the urine flow dynamic index also had been improved a lot in two groups,various indexes in the observation group were higher than that in the control group,with significant difference( P < 0. 05). Rate of adverse reaction in observation group was 2. 00%( 1 /50),which was significantly lower than that in control group 30%( 15 /50),with significant difference( P <0. 05). The improvement time of average urinary incontinence in observation group was( 6. 45 ± 2. 23),which was significantly shorter than that in control group( 8. 76 ± 3. 21),with significant difference( P < 0. 05). Hospitalization costs in observation group was( 4 544. 56 ± 543. 45),which was significantly lower than those in control group( 6 566. 38 ± 432. 23),with significant difference( P < 0. 05). CONCLUSIONS: The clinic efficacy of application of estradiol and midodrine hydrochloride in vaginal for patients with mild-to-moderate stress urinary incontinence is safe and effective,with fewer adverse reactions. The method can lighten the economic burden of the patients,and it is worthy of further clinical promotion and application.
Pages: 999-1001
Year: 2015 Issue: 8
Journal: Evaluation and Analysis of Drug-Use in Hospital of China
Keyword: Stress urinary incontinence; Vaginal administration; Midodrine hydrochloride; TVT operation;
Abstract: OBJECTIVE: To probe into the clinic efficacy and safety of application of estradiol and midodrine hydrochloride in vaginal for patients with mild-to-moderate stress urinary incontinence. METHODS: 100 cases in Xinrongqi Hospital of Foshan Shunde Distinct from Jun. 2012 to Oct. 2015 were selected to be divided into the control group and observation group according to the random number table,with 50 cases in each group. The observation group received estradiol and midodrine hydrochloride in vaginal,the experimental group underwent TVT operation therapy. The clinic efficacy and self evaluation,the urine flow dynamic index before and after treatment,the adverse reactions,the improvement time of median average urinary incontinence and hospitalization costs and some other indexes were observed in two groups. RESULTS: After treatment,volume of urinary incontinence and self evaluation score in two groups both had an obvious improvement compared with before treatment,and the improvement in observation group was better than that in control group,with significant difference( P < 0. 05); the urine flow dynamic index also had been improved a lot in two groups,various indexes in the observation group were higher than that in the control group,with significant difference( P < 0. 05). Rate of adverse reaction in observation group was 2. 00%( 1 /50),which was significantly lower than that in control group 30%( 15 /50),with significant difference( P <0. 05). The improvement time of average urinary incontinence in observation group was( 6. 45 ± 2. 23),which was significantly shorter than that in control group( 8. 76 ± 3. 21),with significant difference( P < 0. 05). Hospitalization costs in observation group was( 4 544. 56 ± 543. 45),which was significantly lower than those in control group( 6 566. 38 ± 432. 23),with significant difference( P < 0. 05). CONCLUSIONS: The clinic efficacy of application of estradiol and midodrine hydrochloride in vaginal for patients with mild-to-moderate stress urinary incontinence is safe and effective,with fewer adverse reactions. The method can lighten the economic burden of the patients,and it is worthy of further clinical promotion and application.
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