Expression and clinical significance of EGFR and P53 in endometrial carcinoma
Author(s): SHEN Yun, DOU Hongtao, HUANG Peng
Pages: 253-256
Year: 2015 Issue: 4
Journal: Journal of Binzhou Medical University
Keyword: Endometrial carcinoma; Immunohistoche-mistry;
Abstract: Objective To discuss the expression and significance of EGFR and P53 in endometrial cancer .Methods Collect cases of hysterectomy in our hospital between January 2013 and October 2013 ,and choose 40 cases of endometrial cancer tissue sections ,20 cases of patients with atypical hyperplasia endometrium tissue section and 20 cases of normal uterine endometrial bi‐opsy .Eighty cases of biopsy patients enrolled underwent EGFR and P53 determination by immunohistochemical methods ,the test results were analyzed .Results ① EGFR and P53 positive expression in endometrial cancer organizations are significantly higher than the normal period of endometrial proliferation ,atypical hyperplasia of endometrium ,the comparison between three groups was statistically significant (P<0.05) .②There were correlations between the expression of EGFR and muscular infil‐tration of endometrial carcinoma and lymphatic metastasis ,and no correlation with clinical stage ,histological grade ,age and whether menopause (P>0.05) .③ There was a positive correlation between the expression of EGFR and P53 in endometrial carcinoma statistically(Rs= 0.961 ,P=0.002) .Conclusion EGFR and P53 may be one of the pathogenesis of endometrial car‐cinoma ,and its high expression can be used as a judge of the important indices for endometrial cancer progression .Combined de‐tection of EGFR and P53 in diagnosis of endometrial carcinoma and prognosis prediction is more meaningful ,and can provide certain reference for endornetrial cancer targeted therapy .
Pages: 253-256
Year: 2015 Issue: 4
Journal: Journal of Binzhou Medical University
Keyword: Endometrial carcinoma; Immunohistoche-mistry;
Abstract: Objective To discuss the expression and significance of EGFR and P53 in endometrial cancer .Methods Collect cases of hysterectomy in our hospital between January 2013 and October 2013 ,and choose 40 cases of endometrial cancer tissue sections ,20 cases of patients with atypical hyperplasia endometrium tissue section and 20 cases of normal uterine endometrial bi‐opsy .Eighty cases of biopsy patients enrolled underwent EGFR and P53 determination by immunohistochemical methods ,the test results were analyzed .Results ① EGFR and P53 positive expression in endometrial cancer organizations are significantly higher than the normal period of endometrial proliferation ,atypical hyperplasia of endometrium ,the comparison between three groups was statistically significant (P<0.05) .②There were correlations between the expression of EGFR and muscular infil‐tration of endometrial carcinoma and lymphatic metastasis ,and no correlation with clinical stage ,histological grade ,age and whether menopause (P>0.05) .③ There was a positive correlation between the expression of EGFR and P53 in endometrial carcinoma statistically(Rs= 0.961 ,P=0.002) .Conclusion EGFR and P53 may be one of the pathogenesis of endometrial car‐cinoma ,and its high expression can be used as a judge of the important indices for endometrial cancer progression .Combined de‐tection of EGFR and P53 in diagnosis of endometrial carcinoma and prognosis prediction is more meaningful ,and can provide certain reference for endornetrial cancer targeted therapy .
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