Effects of Probiotics on Liver Function and Carbohydrate Metabolism in Patients with Nonalco -holic Fatty Liver Disease
Author(s): YI Yanrong, ZENG Ya
Pages: 1132-1133,1136
Year: 2015 Issue: 6
Journal: Journal of Clinical Research
Keyword: Biological Products; Fatty Liver; Liver Function Tests; Tumor Necrosis Factor-al-pha; Insulin Resistance;
Abstract: Objective]To explore the clinical effects and mechanism of probiotics in patients with nonalco ‐holic fatty liver disease .[Methods] A total of 80 patients with nonalcoholic fatty liver disease were randomly divided into observation and control groups ( n = 40 each) .Control group received an intravenous drip of re‐duced glutathione plus an oral intake of polyene phosphatidyl choline .And treatment group had an additional intake of bacillus subtilis enterococcus duplex living bacterium .Enzyme‐linked immunosorbent assay (ELISA) was employed for detecting the changes of serum tumor necrosis factor‐alpha (TNF alpha) before and after treatment .And the levels of fasting glucose ,total cholesterol ,triglyceride and liver function parameters were recorded .The steady‐state model assessment of insulin resistance index (IR) was performed .[Results] The serum TNF alpha level significantly declined than before treatment ( P < 0 .05 ) .And IR significantly de‐creased than before treatment ( P < 0 .05) .In observation group after treatment ,serum level of TNF alpha and IR declined obviously compared with before treatment ( P < 0 .05) .After treatment ,the serum levels of ALT (alanine aminotransferase) ,AST (aspartate aminotransferase) ,GGT (gamma glutamyl transpeptidase) and TBil (total bilirubin) were significantly lower than those before treatment ( P < 0 .05) .The observation group declined more obviously ( P < 0 .05) .[Conclusion] Probiotics can lower the serum level of TNF and im‐prove liver function for patients with nonalcoholic fatty liver disease .
Pages: 1132-1133,1136
Year: 2015 Issue: 6
Journal: Journal of Clinical Research
Keyword: Biological Products; Fatty Liver; Liver Function Tests; Tumor Necrosis Factor-al-pha; Insulin Resistance;
Abstract: Objective]To explore the clinical effects and mechanism of probiotics in patients with nonalco ‐holic fatty liver disease .[Methods] A total of 80 patients with nonalcoholic fatty liver disease were randomly divided into observation and control groups ( n = 40 each) .Control group received an intravenous drip of re‐duced glutathione plus an oral intake of polyene phosphatidyl choline .And treatment group had an additional intake of bacillus subtilis enterococcus duplex living bacterium .Enzyme‐linked immunosorbent assay (ELISA) was employed for detecting the changes of serum tumor necrosis factor‐alpha (TNF alpha) before and after treatment .And the levels of fasting glucose ,total cholesterol ,triglyceride and liver function parameters were recorded .The steady‐state model assessment of insulin resistance index (IR) was performed .[Results] The serum TNF alpha level significantly declined than before treatment ( P < 0 .05 ) .And IR significantly de‐creased than before treatment ( P < 0 .05) .In observation group after treatment ,serum level of TNF alpha and IR declined obviously compared with before treatment ( P < 0 .05) .After treatment ,the serum levels of ALT (alanine aminotransferase) ,AST (aspartate aminotransferase) ,GGT (gamma glutamyl transpeptidase) and TBil (total bilirubin) were significantly lower than those before treatment ( P < 0 .05) .The observation group declined more obviously ( P < 0 .05) .[Conclusion] Probiotics can lower the serum level of TNF and im‐prove liver function for patients with nonalcoholic fatty liver disease .
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