The role of β- defensin in the process of infection and inflammation
Author(s): JIN Xin, ZHANG Man, FAN Yan-ru, WANG Pei, YANG Yin-feng, College of Veterinary Medicine, Inner Mongolia Agricultural University
Pages: 55-57
Year: 2015 Issue: 13
Journal: Heilongjiang Animal Science and Veterinary Medicine
Keyword: β-defensin; host defense peptide; innate immunity; immunomodulatory activity; infection; inflammation; advances;
Abstract: Defensins constitute the largest group of host defence peptides in the body of animals during the entire course of evolution. These cysteine- rich cationic peptides have a broad spectrum antimicrobial activity,and can effectively kill bacteria,yeast,viruses,and other microorganisms. Therefore,defensins are a major component of innate immunity in the organisms. The functions of defensins in immunomodulation have been widely investigated. This article reviews the latest advances in the immunomodulatory activity of β- defensins as well as the role of β- defensins in the process of infection and inflammation.
Pages: 55-57
Year: 2015 Issue: 13
Journal: Heilongjiang Animal Science and Veterinary Medicine
Keyword: β-defensin; host defense peptide; innate immunity; immunomodulatory activity; infection; inflammation; advances;
Abstract: Defensins constitute the largest group of host defence peptides in the body of animals during the entire course of evolution. These cysteine- rich cationic peptides have a broad spectrum antimicrobial activity,and can effectively kill bacteria,yeast,viruses,and other microorganisms. Therefore,defensins are a major component of innate immunity in the organisms. The functions of defensins in immunomodulation have been widely investigated. This article reviews the latest advances in the immunomodulatory activity of β- defensins as well as the role of β- defensins in the process of infection and inflammation.
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