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Synthesis of 2-nitrophenyl-1,4,5-triaryl-1H-imidazole Derivatives
Author(s): 
Pages: 14-15
Year: Issue:  13
Journal: Guangdong Chemical Industry

Keyword:  ayl imidazoleone potsynthesis;
Abstract: Based on the one pot reaction of benzil, ammonium acetate, nitrobenzaldehyde and aminopyridine to afford the 1-(pyridin-2)-2(2-nitrophenyl)-4,5-diphenylimidazole, the different reaction conditions(ratio of mol, solvent, and time) were investigated and the optimal conditions were obtained. Under the optimal condition(the 1∶1∶1∶1 ratio of substrates and the 5 hours of time reaction in refluxing acetic acid), aminopyridine was replaced by the aminothiazole and aniline, respectively to react with other three components. The result showed that the three amino group compounds are suitable to this reaction and 2-nitrophenyl-1,4,5-triarylimidazole derivatives were offored in moderate yields.
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