Author(s): ZHANG Fa-qian, JIN Xiao-qi, ZHANG Yan-na, HAN Jing, WU Xia
Pages: 1180-1184,1189
Year: 2015 Issue:  7
Journal: Applied Chemical Industry
Keyword:  hollow mesoporous silica spheres; N; N-dimethylformamide; ibuprofen; crystallization tem-perature;
Abstract: Hollow mesoporous silica spheres( H-BMMs)were prepared under room temperature and hy-drothermal condition with different additions of N,N-dimethylformamide( DMF)by using obtained RF la-tex and cetyltrimethylammonium bromide( CTAB )as dual templates. The morphology and structure of H-BMMs were characterized by using XRD,TEM,N2 adsorption-desorption and FTIR techniques. In addi-tion,its drug-loading application was preliminary investigated using ibuprofen as a model drug. The results showed that H-BMMs showed high specific surface area(1 100 m2/g)and narrowpore size distribution centered at 2. 3 nm. Thereafter,the narrowpore size of H-BMMs decreased with the increase of DMF and overhigh crystallization temperature can completely destroy the mesoporous pore. In addition,H-BMMs showed high drug-loading potential(32%).