Author(s): YE Jiangang, DAI Zhujian, CHEN Xinfu, LIU Ning
Pages: 8-11
Year: 2015 Issue:  2
Journal: Journal of Hubei Institute for Nationalities（Medical Edition）
Keyword:  Video-assisted thoracoscopic surgery ( VATS ); non-small cell lung cancers; im-mune;
Abstract: Objective To compare immunosuppression to lobectomy in lung cancer patients with video-assisted thoracoscopic surgery ( VATS) and conventional thoracotomy.Methods A total of 162 patients who underwent either a VATS or a CLT lobectomy for early non-small cell lung cancers in our hospital from May 2012 to May 2014 were recruited.Blood samples of the pa-tients were taken pre-operatively and at 1 d,3 d and 7d postoperations for analyses of CD3+T, CD4+T,CD8+T,CD4+/CD8+T and IgG,IgA,IgM.Results There was no significant difference for all the indicators between the two groups.The IgG levels decreased markedly at 1 d postopera-tively in both groups,but much lower in CLT patients.CD3+T,CD4+T after operation of the two groups were significantly lower than those before operation.Patients in the CLT group had sig-nificantly lower at CD3+T,CD4+T,CD8+T 1 d post operation than those in the VATS group with statistical significance.Conclusion VATS pulmonary lobectomy is associated with reduced immu-nosuppression compared with the CLT approach, and has great advantages of therapy for early non-small cell lung cancers.