Studies on Anti-Platelet Aggregation of Allitridi in Hypercholesterolemic Rabbits
Author(s): Zhang Shengle Xu Yingjie Lu Tong Department of Biochemistry, Shandong Academy of Medical Science, Jinan
Pages: 677-678+646
Year: 1986 Issue: 11
Journal: Chinese Journal of Integrated Traditional and Western Medicine
Keyword: 蒜素; 血小板聚集率; 高胆固醇血症; 胆固醉; 动物模型; 血小板数; 作用机理; 放射免疫测定盒; 体重比; 蒲黄;
Abstract: Thirty-two New Zealand rabbits weighing 1.5～2.5 kg were divided into three groups:group Ⅰ(the control group,n=10);group Ⅱ(n=11)and group Ⅲ(n=11).They were all fed a common-stock diet.Except for the control group,group Ⅱ received cholesterol(0.5 g/kg body weight)daily,while group Ⅲ was fed 0.5 g/kg of cholesterol plus the Allitridi(diallyl trisulfide,20 mg/kg).Blood cholesterol,platelet aggregation, platelet cAMP and cGMP index were determined by the usual techniques at fixed time.The observation was finished at the end of the 15th week.The rise in serum cholesterol was significantly reduced by Allitridi during the 15 weeks period of study.Platelet aggregation in group Ⅱ was significantly higher than that in group Ⅰ(P<0.05),while in group Ⅲ,it was close to the control group but significantly lower than that in group Ⅲ(P<0.01).There was a negative correlation between platelet cAMP and platelet aggregation(r= —0.42,P<0.05).Platelet cAMP in group Ⅲ was little higher than that in the control group(P>0.05),but significantly higher than that in group Ⅱ(P<0.001).There was no difference of platelet cGMP between group Ⅱ and group Ⅲ.It is suggested that Allitridi has a powerful anti-aggregating effect on platelet in hypercholesterolemic rabbits and its inhibition of platelet aggregation is mediated by an increase of platelet cAMP.
Pages: 677-678+646
Year: 1986 Issue: 11
Journal: Chinese Journal of Integrated Traditional and Western Medicine
Keyword: 蒜素; 血小板聚集率; 高胆固醇血症; 胆固醉; 动物模型; 血小板数; 作用机理; 放射免疫测定盒; 体重比; 蒲黄;
Abstract: Thirty-two New Zealand rabbits weighing 1.5～2.5 kg were divided into three groups:group Ⅰ(the control group,n=10);group Ⅱ(n=11)and group Ⅲ(n=11).They were all fed a common-stock diet.Except for the control group,group Ⅱ received cholesterol(0.5 g/kg body weight)daily,while group Ⅲ was fed 0.5 g/kg of cholesterol plus the Allitridi(diallyl trisulfide,20 mg/kg).Blood cholesterol,platelet aggregation, platelet cAMP and cGMP index were determined by the usual techniques at fixed time.The observation was finished at the end of the 15th week.The rise in serum cholesterol was significantly reduced by Allitridi during the 15 weeks period of study.Platelet aggregation in group Ⅱ was significantly higher than that in group Ⅰ(P<0.05),while in group Ⅲ,it was close to the control group but significantly lower than that in group Ⅲ(P<0.01).There was a negative correlation between platelet cAMP and platelet aggregation(r= —0.42,P<0.05).Platelet cAMP in group Ⅲ was little higher than that in the control group(P>0.05),but significantly higher than that in group Ⅱ(P<0.001).There was no difference of platelet cGMP between group Ⅱ and group Ⅲ.It is suggested that Allitridi has a powerful anti-aggregating effect on platelet in hypercholesterolemic rabbits and its inhibition of platelet aggregation is mediated by an increase of platelet cAMP.
Related Articles