Author(s): Wang Qi, Li Dong-fang, Wang Tong and Li Jia-tai
Pages: 125-130
Year: 1990 Issue:  2
Journal: Chinese Journal of Antibiotics
Keyword:  Sultamicillin; Sulbactam; Ampicillin; β-lactamases; In-vitro antibacterial action;
Abstract: Sultamicillin is at oral β-lactam antibiotic comprising ampicillin and the β-lactamase inhibitor-sulbactam(Cp45899). The compound has strong antibacterial activity against β-lactamase producing resistant bacteria, especially ampicillin-resistant Staph. aureus.In vitro antibacterial activity of home-made sultamicillin against 511 strains of clinical isolates compared with other 9 antibiotics was reported in the paper. The results showed that sultamicillin had good antibacterial activity against 1.3 species of common organisms except PS, aeruginosa. The antibacterial activity of sultamicillin against most of bacteria was 2 ~ 64 times stronger than that of ampicillin , especially Staph aureus , E, coli, Proteus sp and Enterbacteriaceaes The values of MIC90 of sultamicillin against Staphylacacci, A. anitratus and Shigella were 4~16 mg/L that were 8-16 times less than MIC90s of ampicillin. The values of MIC50 (8~32mg/L)against E, coli. Enter. cloacae. E. aerogenes,Kl. pneumoniae, Serratia and Citrobacter were 4 ~ 8 times less than those of ampicillin. The results of killing curve against Staph. aureus and E. aerogenes showed that sultamicillin had much higher bactericidal activity than ampicillin and sulbactam alone, otherwise the compound had similar bactericidal activity to the combination of ampicillin and sulbactamSultamicillin has more advantages than ampicillin to that it can be administered orally and shows it has antibacterial activity against β-lactamase-producing strains and it also shows good antibacterial activity against most common organisms. The compound can become one of the first choice drugs in the treatment of infectious diseases.