Author(s): Hou Chun-qiu and wang Qi-nan
Pages: 262-266
Year: 1989 Issue:  4
Journal: Chinese Journal of Antibiotics
Keyword:  Ceftazidime; Pharmacokinetics; Tissue concentration;
Abstract: The pharmacokinetics of ceftazidime were studied in dogs. Six healthy dogs were all given a single dose of 20mg/kg. Both intramuscular and intravenous administrations were used. The drug serum and tissue levels were measured by bioassay method.The serum concentration-time profiles after intramuscular injections conformed to the one-compartment open model; while those of intravenous injections monformed to the two-compartment open model. The mean peak level was 167. 28±15.73 μg/ml after intravenous injections, and was 54. 86±11.42 ,μg/ml for the intramuscular route at the post-administration time of 0.75 hour. The elimination halflives after intramuscular and intravenous injections were 1.44 and 1.61 hours,respectively.The apparetn volumes of distribution were 0.34 and 0.35 L/kg, respectively.Tissue concentrations were determined 1 hour after intravenous and intramuscular injections of 20 mg/kg. The concentration in the renal tissue was the highest, reaching 189.03 ± 79.38 μg/ml(im) and 257.04±59. 19 μg/ml(iv), and the bile concentration was the next. The concentrations in decreasing order in other tissues were uterine, prostatic, pulmonary, hepatic, small intestinal, pancreatic, muscular, cardiac and splenic. The concentrations in the brain were 0.31±0.1 μg/ml(im) and 0.77± 0.096μg/ ml(iv).