FULONGMYCIN, AN ANTIFUNGAL ANTIBIOTIC PRODUCED BY STREPTOMYCES STRAIN B1829
Author(s): Wang Nan-jin, Zhang Xie-xian, Fu Yuan, Zhang Wei-xi, Sun Jin-Jin and Huang Ming-yu
Pages: 402-407
Year: 1988 Issue: 6
Journal: Chinese Journal of Antibiotics
Keyword: Fulongmycin; Steptomyes B1892; Physical and chemical characteris-tics; structure determination;
Abstract: In the course of screening for new antifungal antibiotics from Streptomyces, an antifungal antibiotic, Fulongmycin was discovered in culture mycelium and broth of a Streptomyces B1829 which was isolated from the soil sample collected in Fuzhou. The antibiotic was extracted by acetone from the mycelium and purified by column chromatography. The physical and chemical characteristics and UV, IR, NMR and MS spectra showed Fulongmycin is a pentaene antibiotic similar to flavofungin-and Mycoticin but in different ratio of A and B components. The ratio of A and B of Fulongmycin is 1:2, while Flavofungin is 10:1 and Mycoticin is 1:1 respectively. The characteristics of the producing strain B1829 were described.
Pages: 402-407
Year: 1988 Issue: 6
Journal: Chinese Journal of Antibiotics
Keyword: Fulongmycin; Steptomyes B1892; Physical and chemical characteris-tics; structure determination;
Abstract: In the course of screening for new antifungal antibiotics from Streptomyces, an antifungal antibiotic, Fulongmycin was discovered in culture mycelium and broth of a Streptomyces B1829 which was isolated from the soil sample collected in Fuzhou. The antibiotic was extracted by acetone from the mycelium and purified by column chromatography. The physical and chemical characteristics and UV, IR, NMR and MS spectra showed Fulongmycin is a pentaene antibiotic similar to flavofungin-and Mycoticin but in different ratio of A and B components. The ratio of A and B of Fulongmycin is 1:2, while Flavofungin is 10:1 and Mycoticin is 1:1 respectively. The characteristics of the producing strain B1829 were described.
Related Articles