THE IN VITRO ANTIBACTERIAL ACTIVITY OF HOME-NMADE CEFOPERAZONE
Author(s): Duan Ming-gang, Wang Qi-nan, Van Si-zhuang, Du Ji-zhao Jiang Yu-fu, Zhen Xing-pin, Yu Deng-gao and Li Chong-zhi
Pages: 346-350
Year: 1988 Issue: 5
Journal: Chinese Journal of Antibiotics
Keyword: cefoperazone; in vitro antibacterial activity;
Abstract: In vitro antibacterial activities of Home-made cefoperazone against 440 clinical isolates were evaluated by a two-fold broth dilution method and compared with those of German-made cefoprazone. Results showed that the cumulative percentage MIC and MBC of both agents were essentially the same for all strains tested. 83.9% of the strains were inhibited at 8 μg/ml by either agent. Staphylococcus aureus was susceptible to Home-made cefoperazone(MICs≤8μg/ml; MIC90, 4μg/ml). Its actions on different species of bacteria of Enterobacteriaceae were remarkable. MIC90 was 0.06 μg/ml for Shigella species, 8μg/ml for Escherichia coli and Proteus species MIC50 s were 0.125 to 0.25μg/ml for Salmonella species, Hafnia species, Enterobacter aerogenes and Klebsiella pneumoniae and MIC90s were 16 to 32 μg/ml. Citrobacter species were less susceptible (MIC50, 4μg/ml; MIC90,64ug/ml). Home-made cefoperazone showed a good activity for Pseudomonas aeruginosa (MIC50, 4 μg/ml; MIC90, 32 μg/ml), and the majority (70%)which was inhibited at or below 8μg/ml. Strains of Streptococcus faecalis, Enterobacter cloacae and Acinetobacter were less susceptible or resistant to this agent.
Pages: 346-350
Year: 1988 Issue: 5
Journal: Chinese Journal of Antibiotics
Keyword: cefoperazone; in vitro antibacterial activity;
Abstract: In vitro antibacterial activities of Home-made cefoperazone against 440 clinical isolates were evaluated by a two-fold broth dilution method and compared with those of German-made cefoprazone. Results showed that the cumulative percentage MIC and MBC of both agents were essentially the same for all strains tested. 83.9% of the strains were inhibited at 8 μg/ml by either agent. Staphylococcus aureus was susceptible to Home-made cefoperazone(MICs≤8μg/ml; MIC90, 4μg/ml). Its actions on different species of bacteria of Enterobacteriaceae were remarkable. MIC90 was 0.06 μg/ml for Shigella species, 8μg/ml for Escherichia coli and Proteus species MIC50 s were 0.125 to 0.25μg/ml for Salmonella species, Hafnia species, Enterobacter aerogenes and Klebsiella pneumoniae and MIC90s were 16 to 32 μg/ml. Citrobacter species were less susceptible (MIC50, 4μg/ml; MIC90,64ug/ml). Home-made cefoperazone showed a good activity for Pseudomonas aeruginosa (MIC50, 4 μg/ml; MIC90, 32 μg/ml), and the majority (70%)which was inhibited at or below 8μg/ml. Strains of Streptococcus faecalis, Enterobacter cloacae and Acinetobacter were less susceptible or resistant to this agent.
Related Articles