SYNTHETIC STUDIES OF THE DERIVATIVES OF AMOXICILLIN
Author(s): Yao Qing-xiang, Wan Yong-fen and Liu Ren-yong
Pages: 109-115
Year: 1987 Issue: 2
Journal: Chinese Journal of Antibiotics
Keyword: 羟氨苄青霉素; 三嗪; 抗菌活性; 阴性细菌; 甲氧; 最小抑菌浓度; 核磁共振光谱; 芳基; 红外光谱; 化学结构;
Abstract: We have synthesized nine N-（2-aryltriazmylcarbonyl） amoxicillin derivatives which hitherto have not been found in the literature. The structures of these compounds were determined by elemental analysis, IR, 1HNMR and 13CNMR spectrum respectively. The antibacterial activity of phentricillin, tolutricillin, metotricillin and clotricillin against Sta-phylococcus aureus are higher than that of triazinocillin （BL-P1908）, and the antibacterial activity of tolutricillin against Pseudomonas aeruginosa is higher than that of triazinocilhn.
Pages: 109-115
Year: 1987 Issue: 2
Journal: Chinese Journal of Antibiotics
Keyword: 羟氨苄青霉素; 三嗪; 抗菌活性; 阴性细菌; 甲氧; 最小抑菌浓度; 核磁共振光谱; 芳基; 红外光谱; 化学结构;
Abstract: We have synthesized nine N-（2-aryltriazmylcarbonyl） amoxicillin derivatives which hitherto have not been found in the literature. The structures of these compounds were determined by elemental analysis, IR, 1HNMR and 13CNMR spectrum respectively. The antibacterial activity of phentricillin, tolutricillin, metotricillin and clotricillin against Sta-phylococcus aureus are higher than that of triazinocillin （BL-P1908）, and the antibacterial activity of tolutricillin against Pseudomonas aeruginosa is higher than that of triazinocilhn.
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