EXPERIMENTAL STUDIES ON THE EFFECTS OF CHINA-MADE ACLACINOMYCIN B ON THE GROWTH OF THE MOUSE L1210 LEUKEMIA CELL(IN VITRO)AND AGAINST LEWIS LUNG(IN VIVO)
Author(s): Shea Wei-ming Yan Hui-fang-and Pan Xian-xin
Pages: 290-295
Year: 1983 Issue: 5
Journal: Chinese Journal of Antibiotics
Keyword: 阿克拉霉素; 白血病细胞; L1210; Lewis肺癌; 抗瘤作用; 肺转移; 柔红霉素; 蛋白质合成; 抑制作用; 腹腔给药;
Abstract: The effects of China-made Aclacinomy-cin B(ACM B) on RNA, DNA and protein synthesis in mouse lymphocytic leukemia L1210 cells have been studied. In addition, its inhibitory effects on mice bearing Lewis lung carcinoma and its lung metastasis have also been observed. Our experimental results showed that ACM B caused significant inhibitory effects on RNA and DNA syntheses of L 1210 primary cells,which on RNA synthesis was much more remarkable than on DNA synthesis and more intense than those of Adriamycin and Daunomycin. It produced, however, a less pronounced inh-ibitory effect on protein synthesis of mouse L 1210 primary cells. Our results also showed that ACM B administered through i.p. or p. o. all had distinct inhibitory effects on subcutaneous tumor growth and lung metastasis formation in mice bearing Lewis lung carcinoma.
Pages: 290-295
Year: 1983 Issue: 5
Journal: Chinese Journal of Antibiotics
Keyword: 阿克拉霉素; 白血病细胞; L1210; Lewis肺癌; 抗瘤作用; 肺转移; 柔红霉素; 蛋白质合成; 抑制作用; 腹腔给药;
Abstract: The effects of China-made Aclacinomy-cin B(ACM B) on RNA, DNA and protein synthesis in mouse lymphocytic leukemia L1210 cells have been studied. In addition, its inhibitory effects on mice bearing Lewis lung carcinoma and its lung metastasis have also been observed. Our experimental results showed that ACM B caused significant inhibitory effects on RNA and DNA syntheses of L 1210 primary cells,which on RNA synthesis was much more remarkable than on DNA synthesis and more intense than those of Adriamycin and Daunomycin. It produced, however, a less pronounced inh-ibitory effect on protein synthesis of mouse L 1210 primary cells. Our results also showed that ACM B administered through i.p. or p. o. all had distinct inhibitory effects on subcutaneous tumor growth and lung metastasis formation in mice bearing Lewis lung carcinoma.
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