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yi ding ji zuo zuo li fu mei su dui ma feng de shi yan zhi liao yan jiu
Author(s): 
Pages: 32-34
Year: Issue:  4
Journal: Chinese Journal of Antibiotics

Keyword:  麻风患者实验治疗鼠麻风感染模型足垫鼠足杀菌药抗麻风药动力法瘤型麻风;
Abstract: <正> 发展新的抗麻风药物是麻风治疗研究的重要内容之一,首要目的是发现更强有力的杀菌药。我们应用鼠麻风菌感染模型观察17种利福霉素衍生物的治疗效果并与利福平(简称RFP)作比较,发现异丁基哌嗪力复霉素(简称R-76-1)明显超过RFP,即使R-76-1的剂量减少到RFP的1/3,仍然取得稍优于RFP的疗效。为此,我们进一步观察R-76-1对麻风的实验治疗效果,并与RFP作比较。已知RFP在麻风菌鼠足垫感染模型显示很强的杀菌作用,一定剂量下用常规动力法给药(足垫接种麻风菌后70天到140天给药),
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