The research of DNA methylation and its causation in the pathogenesis of essential hypertension
Author(s): FAN Rui, ZHONG Qi-Long, MAO Shu-Qi, ZHU Wen, ZHANG Li-Na, Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University
Pages: 590-594
Year: 2015 Issue: 5
Journal: Chinese Bulletin of Life Sciences
Keyword: essential hypertension; gene; epigenetic; DNA methylation;
Abstract: DNA methylation, one of the earliest discovered epigenetic manners, is currently a hot topic in life sciences. Although methylation does not change DNA sequence, it plays an important regulatory role in the process of gene expression. Besides, as one of the major public health problems, essential hypertension(EH) is an important human disease, caused by a combination of genetic and environmental factors, which is considered to be regulated by epigenetic, such as DNA methylation. This paper summarizes recent progress regarding the association between DNA methylation and the pathogenesis of essential hypertension.
Pages: 590-594
Year: 2015 Issue: 5
Journal: Chinese Bulletin of Life Sciences
Keyword: essential hypertension; gene; epigenetic; DNA methylation;
Abstract: DNA methylation, one of the earliest discovered epigenetic manners, is currently a hot topic in life sciences. Although methylation does not change DNA sequence, it plays an important regulatory role in the process of gene expression. Besides, as one of the major public health problems, essential hypertension(EH) is an important human disease, caused by a combination of genetic and environmental factors, which is considered to be regulated by epigenetic, such as DNA methylation. This paper summarizes recent progress regarding the association between DNA methylation and the pathogenesis of essential hypertension.
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