Clinical observation of dexmedetomidine with different doses combined with bupivacaine on arthroscopic surgery in patients with subarachnoid block
Author(s): GE Dong-mei, Shengli Oilfield Central Hospital
Pages: 814-819
Year: 2015 Issue: 7
Journal: World Phytomedicines
Keyword: Dexmedetomidine Hydrochloride Injection; bupivacaine; subarachnoid block;
Abstract: Objective To observe the effect of dexmedetomidine with different doses combined with bupivacaine on arthroscopic surgery in patients with subarachnoid block. Methods Patients（80 cases） who accepted arthroscopic surgery in Shengli Oilfield Central Hospital from January 2013 to January 2015 randomly divided into control, dexmedetomidine low-, mid-, and high-dose groups（20 cases in each group）. Subarachnoid puncture was through the lumbar line 3-4 clearance, patients in the control group were given 0.75% bupivacaine 11.25 mg, the patients in the low-, mid-, and high-dose groups were respectively given Dexmedetomidine Hydrochloride Injection 5, 10, 15 μg on the basis of the control group. The sensory and motor block effect and maintain time, reached time of highest sensory blockade plane, maintain time of lumbar hemp, blood pressure, heart rate, consciousness change of different time in perioperative, and occurrence of adverse events in four groups were observed. Results The reached time of feel plane to T10（t1）, reached time of highest sensory blockade plane（t2）, and reached time of motion block up to level 3（t3）in low-, mid-, and high-dose groups were significantly shorter than those in the control group. The t1, t2, and t3 in the high-dose group were significantly shorter than those in the low-, mid-dose group, with significant difference（P < 0.05）. Sensory and motor block time, lumbar hemp duration in the low-, mid-, and high-dose groups were significantly longer than those in the control group, and those observational indexes in high-dose groups were significantly longer than the low-, mid-dose group, with significant difference（P < 0.05）. Ramsay score in the high-dose group was highest in 15, 30, and 60 min after anesthesia, which was significantly higher than those of other three groups（P < 0.05）. The incidence of bradycardia and hypotension in the high-dose group was highest, and the incidence of chills, nausea and vomiting, and headache in four groups had no statistically significant difference. Conclusion Dexmedetomidine with 5, 10, 15 μg combined with bupivacaine can shorten the work time of sensory and motor blocked, and can extend the maintain time of block, which can provide good anesthetic effect. But the incidences of bradycardia and hypotension were high in patients with 15 μg dexmedetomidine, which should be applied under close monitoring.
Pages: 814-819
Year: 2015 Issue: 7
Journal: World Phytomedicines
Keyword: Dexmedetomidine Hydrochloride Injection; bupivacaine; subarachnoid block;
Abstract: Objective To observe the effect of dexmedetomidine with different doses combined with bupivacaine on arthroscopic surgery in patients with subarachnoid block. Methods Patients（80 cases） who accepted arthroscopic surgery in Shengli Oilfield Central Hospital from January 2013 to January 2015 randomly divided into control, dexmedetomidine low-, mid-, and high-dose groups（20 cases in each group）. Subarachnoid puncture was through the lumbar line 3-4 clearance, patients in the control group were given 0.75% bupivacaine 11.25 mg, the patients in the low-, mid-, and high-dose groups were respectively given Dexmedetomidine Hydrochloride Injection 5, 10, 15 μg on the basis of the control group. The sensory and motor block effect and maintain time, reached time of highest sensory blockade plane, maintain time of lumbar hemp, blood pressure, heart rate, consciousness change of different time in perioperative, and occurrence of adverse events in four groups were observed. Results The reached time of feel plane to T10（t1）, reached time of highest sensory blockade plane（t2）, and reached time of motion block up to level 3（t3）in low-, mid-, and high-dose groups were significantly shorter than those in the control group. The t1, t2, and t3 in the high-dose group were significantly shorter than those in the low-, mid-dose group, with significant difference（P < 0.05）. Sensory and motor block time, lumbar hemp duration in the low-, mid-, and high-dose groups were significantly longer than those in the control group, and those observational indexes in high-dose groups were significantly longer than the low-, mid-dose group, with significant difference（P < 0.05）. Ramsay score in the high-dose group was highest in 15, 30, and 60 min after anesthesia, which was significantly higher than those of other three groups（P < 0.05）. The incidence of bradycardia and hypotension in the high-dose group was highest, and the incidence of chills, nausea and vomiting, and headache in four groups had no statistically significant difference. Conclusion Dexmedetomidine with 5, 10, 15 μg combined with bupivacaine can shorten the work time of sensory and motor blocked, and can extend the maintain time of block, which can provide good anesthetic effect. But the incidences of bradycardia and hypotension were high in patients with 15 μg dexmedetomidine, which should be applied under close monitoring.
Related Articles