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Efficacy and Safety of Fasudil in Treatment of the Left Heart Disease Related to Pulmonary Hypertension
Pages: 871-873
Year: Issue:  7
Journal: Research of Traditional Chinese Medicine

Keyword:  pulmonary hypertensionfasudilleft heart disease;
Abstract: Objective To evaluate the efficacy and safety of fasudil in treatment of the left heart disease(LHD)related to pulmonary hypertension(PH).Methods From2012 January to 2014 June,in department of Cardiology in hospital LHD including hypertension,coronary heart disease,cardiomyopathy and NYHA classification of cardiac functionwas gradeⅡtoⅣ,patients were screened.One hundred and eighty-six patients selected with PH were randomly divided into experimental group(n =92)treated by routine treatment plus fasudil30 mg intravenous drip,and control group(n =94)treated by routine treatment for 2 weeks.Results 6 min walking distance(6MWD),pulmonary artery systolic pressure(PASP),arterial partial pressure of oxygen(PaO2)were observed before and after the treatment.The changes of blood pressure,heart rate were observed before and after treatment in the experimental group.Results Before treatment,there was not statistically significant in6 MWD,PASP,and PaO2 between two groups(P >0.05).After treatment,6MWD and PaO2 increased,PASP was decreased in experimental group,and the degree of improvement was better than that in control group,the difference was statistically significant(P <0.05).Comparison of blood pressure and heart rate of experimental group before and after treatment,differences were not statistically significant(P >0.05).Liver and kidney function,electrolyte had no change before and after the treatment.Further analysis,61 patients preserved left ventricular ejection fraction(LVEF)in experimental group,after treatment,6MWD and PaO2 increased,PASP decreased,the difference was statistically significant(P <0.01).While LVEF decreased in 31 patients,after treatment,6MWD and PaO2 increased,SPAP decreased,the difference was not statistically significant(P >0.05).Conclusion Fasudil can effectively reduce PH in patients with left heart failure,can improve the ability of activities of daily living,and it is safe and efficient.It can improve the degree of life quality obviously in patients with LVEF retention.
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