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Effects of Huazhuo Tongmai Decoction on Caveolin C1 and Cyclophilin A in Rabbit’s Aortas Atherosclerosis
Author(s): 
Pages: 884-886
Year: Issue:  7
Journal: Research of Traditional Chinese Medicine

Keyword:  Huazhuo Tongmai decoctionatherosclerosiscaveolin-1cyclophilin A;
Abstract: Objective To study the effect of Huazhuotongmai compound on the key reverse transcription protein caveolin-1(Cav-1)and cyclophilin A of rabbits with atherosclerosis(AS)and to investigate the possible mechanism of Huazhuo Tongmai decoction(HTD)in preventing AS through promoting reverse cholesterol transport(RCT).Methods Forty New Zealand rabbits were randomly divided into control group,model group,compound group and simvastatin group.The rabbits with AS were remodeled by feeding with simple hypercholesterol diet.The thoracic aortas were stripped for observation of artery plaque formation by HE staining after 15 weeks of drugs delivery.The Cav-1 and cyclophilin A in aortas was tested by Western blotting(WB)and the expression of Cav-1 and cyclophilin A mRNA in aortas was tested by Real-time PCR,which were designed to observe the effects of experiment drugs on proteins related to RCT proteins.Results The results of HE staining show that there was markedly formation of atheromatous plaque on the wall of thoracic aorta,while it was improved in different degrees in medicated groups.The results of WB show that the Cav-1 in model group was significantly lower(P<0.01)compared with control group,the Cav-1 in simvastatin group was higher(P <0.05)compared with model group,while there was no significant differences between compound groups and model group(P >0.05).The expression of cyclophilin A in the model group was significantly higher than that in control group(P <0.05),and those in compound groups and simvastatin group were lower than that in model group(P <0.01).The same results of the expression of Cav-1 mRNA by Real-time PCR was also found,but there was no statistically significance in the expression of cyclophilin A mRNA in model group,which was lower than that in control group.The expression in compound group and simvastatin group were higher than those in model groups.Conclusion The HTD can regulate the expression of Cav-1 and cyclophilin A,promote the outflow of cholesterol in cell,reduce excessive expression of cyclophilin A and formation of foam cells and atherosclerotic plaque,finally reach the anti-atherosclerotic effect.
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