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xue jiang mirnas zai ji xing bing li qi que xue xing nao zu zhong de biao da pu fen xi
Author(s): 
Pages: 932-934
Year: Issue:  7
Journal: Research of Traditional Chinese Medicine

Keyword:  缺血性卒中急性病理期血浆miRNA;
Abstract: 目的探讨缺血性卒中在病理分期的急性期(24 h内)外周血浆中miRNA的表达及临床意义。方法选取急性脑梗死患者和健康对照者各5例。收集急性脑梗死患者发病24 h之内的血浆和健康对照者的清晨空腹血浆。采用TaqManMicroRNA Arrays进行miRNAs表达谱筛选。使用相关统计学软件及统计方法进行数据分析。结果与健康对照组相比,在缺血性脑卒中发病24 h内外周血浆中存在差异表达的miRNA。本研究共检测有统计意义的显著差异表达的miRNA66个,其中表达上调的39个,下调的27个。上下调倍数变化最显著的miR4498上调7.84倍(foldchange=7.84),miR6 7 6-5P下调为0.1 6 7(foldchange=0.167),P均<0.05。结论急性缺血性脑卒中发病24 h内外周血浆中即存在差异表达的miRNA,这些差异表达miRNA可能与缺血性卒中早期的缺血缺氧应激,血脑屏障破坏,早期再灌注损伤等有关,也有可能作为缺血性卒中早期干预新的治疗方向和靶点。
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