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Effects of human gastric cancer cell line SGC-7901 by p21WAF1/CIP1 gene transduction plus cisplatin
Author(s): 
Pages: 204-206
Year: Issue:  3
Journal: CHINA ONCOLOGY

Keyword:  胃肿瘤p21WAF1/CIP1基因基因治疗;
Abstract: 目的:探讨腺病毒介导的p21WAF1/CIP1基因(p21基因)在人胃癌细胞系SGC-7901中的表达及其联合顺铂化疗对胃癌细胞生长和荷瘤小鼠的作用.方法:采用腺病毒载体携带p21基因感染人胃癌细胞系,用流式细胞仪测定p21基因对SGC-7901细胞周期的影响,并与DDP联合应用,观察p21基因和(或)DDP对SGC-7901细胞系和荷瘤小鼠的作用.结果:腺病毒介导的p21基因可在胃癌细胞系SGC-7901中过度表达,使胃癌细胞系S期含量下降,抑制其生长,并可诱导胃癌细胞的凋亡;p21基因联合DDP作用使SGC-7901细胞G2/M含量明显下降,并可抑制荷瘤小鼠肿瘤细胞的生长,且联合作用比单一用药作用更明显.结论:腺病毒介导的p21基因可抑制人胃癌细胞系的生长,抑制瘤体的生长,结合化疗药物其作用更强,为临床应用提供了依据.
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