The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
Expression of resistance-related genes in lung carcinomas tissue and its clinical significance
Author(s): 
Pages: 220-222
Year: Issue:  3
Journal: CHINA ONCOLOGY

Keyword:  P-糖蛋白多药耐药相关蛋白肺耐药蛋白多药耐药;
Abstract: 目的:探讨肺癌组织中耐药相关基因的表达及其临床意义.方法:应用免疫组化技术检测治疗前肺癌组织标本中P-gp、MRP和LRP表达.结果:72例非小细胞肺癌中P-gp、MRP、LRP阳性率分别为61%,49%,65%,并有部分共表达.9例小细胞肺癌中P-gp、MRP、LRP阳性率分别为56%,22%,44%,也有部分共表达.在TNM各分期中P-gp、MRP、LRP阳性表达无明显差异(P>0.05),随访中化疗有效组P-gp、MRP、LRP阳性表达分别为29%(4/14)、36%(5/14)、21%(3/14),无效组P-gp、MRP、LRP阳性表达分别为83%(20/24)、67%(16/24)、75%(18/24).有效组P-gp、LRP表达低于无效组(P<0.05),随访中死亡16例,P-gp、MRP、LRP阳性表达分别占43%(7/16),31%(5/16),64%(11/16).LRP阳性组占比例最高,提示LRP阳性表达预后差,其与预后关系密切.结论:肺癌耐药为一多途径多基因参与的过程,联合检测肺癌组织中耐药相关基因的表达有助于判断化疗疗效及预后.
Related Articles
No related articles found