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Expression of neurofilament protein,neuron-specific enolase and synaptophysin in human embryonic tongue tissues
Author(s): 
Pages: 405-409
Year: Issue:  3
Journal: Acta Anatomica Sinica

Keyword:  EmbryoTongueNeurofilament proteinNeuron-specific enolaseSynaptophysinImmunohistochemistryHuman;
Abstract: Objective To explore the distribution of neurofilament protein( NF),neuron-specific enolase( NSE)and synaptophysin( SYN) proteins at the developmental stages of the human embryonic tongue tissue. Methods Immunohistochemistry was used to detect the expressions of NF,NSE and SYN proteins in the tongue tissues of 16 embryos during the second,third and fourth month of human embryonic and fetal development. Results In the embryos at the 2nd,3nd and 4th months of gestation,NF,NSE and SYN proteins expressed in the tongue tissue. With the increase of gestational age,the number and intensity of the positive expression of NF,NSE and SYN in tongue gradually increased. At the 2nd month of gestation,NF,NSE and SYNproteins were a small amount of weakly positive expression,and the intensity values of their positive expression were 135. 83 ± 24. 62,136. 57 ± 15. 23 and 139. 84 ± 21. 40,respectively. At the 3rd month of gestation,the intensity values of NF,NSE and SYN positive expression were 96. 04 ± 23. 37,94. 89 ± 22. 52 and90. 65 ± 21. 08,respectively. At the 4th month of gestation,the intensity values of NF,NSE and SYN positive expression were 79. 02 ± 20. 90,76. 78 ± 21. 27 and 83. 43 ± 25. 90,respectively. One-Way ANOVA and LSD-t test were employed to compare the intensity values of NF,NSE and SYN expressions in tongue tissues detected in the 3 fetal periods. The results of NF,NSE and SYN showed significant difference in the tongue tissue( P < 0. 01). Conclusion At the second to fourth gestation,with the increase of gestational age,the intensity values of NF,NSE and SYN positive expressions are lower.NF,NSE and SYN proteins participate in regulation of the development and differentiation in the nervous system and muscle tissues of tongues in human embryos and fetus.
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