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Bioinformatics analysis of genes related to Parkinson’s disease with LRRK2( G2019S) mutation
Author(s): 
Pages: 304-309
Year: Issue:  3
Journal: Acta Anatomica Sinica

Keyword:  Leucine-rich repeat kinase 2Parkinson’s diseaseDNA microarrayBioinformaticsHuman;
Abstract: Objective To investigate the genes from Parkinson’s disease( PD) patients carrying the mutation of leucine-rich repeat kinase 2( LRRK2) gene( G2019S) and to explore the molecular mechanism of Parkinson’s disease.Methods Microarray dataset GSE22491 from the Gene Expression Omnibus database,the dataset includes 10 PD and 8control samples,and analyzed by bioinformatics methods using Qlucore Omics Explorer( QOE) 3. 0,DAVID and String.Results A total of 1752 genes were identified as differentially expressed genes,of which 191 were up-regulated and 1561 were down-regulated in PD. The main biological pathways involved included ribosome,oxidative phosphorylation,proteasome,leukocyte transendothelial migration,pentose phosphate pathway,citrate cycle,Fc gamma receptor-mediated phagocytosis and genes of SKP2,RBX1,SKP1,CUL1,CUL4 A,etc. They might play important roles in the molecular mechanism of Parkinson’s disease. Conclusion The pathogenesis of PD involves multiple genes,and investigations of these genes may provide valuable insights into the mechanism of PD with mutation of LRRK2 gene( G2019).
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