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Expression of cytochrome P450Ⅱ E1 in colorectal carcinoma complicated with intestinal schistosomiasis
Author(s): 
Pages: 400-404
Year: Issue:  3
Journal: Acta Anatomica Sinica

Keyword:  Colorectal cancerSchistosoma JaponicumCytochrome P450Ⅱ E1ImmunohistochemistryHuman;
Abstract: Objective To study the relationship between cytochrome P450Ⅱ E1( CYPⅡE1) protein expression of colorectal carcinoma complicated with intestinal schistosomiasis and its possible mechanism. Methods Immunohistochemical SP method was applied to detect the CYP Ⅱ E1 protein expression of 60 cases of intestinal schistosomiasis and colorectal cancer tissue,60 cases of colorectal cancer tissue without intestinal infection of Schistosoma japonicum,60 cases of intestinal schistosomiasis infection group,and 50 cases of normal intestinal tissue without infection of Schistosoma japonicum. Results The rates of the cytochrome p450 Ⅱ E1 immunohistochemical positive staining were73. 33% in colorectal carcinoma complicated with intestinal schistosomiasis group,46. 67% in the intestinal schitosoma japonicum infection group,31. 67% in colorectal cancer tissue without intestinal infection of schistosoma japonicum,16%in the normal intestinal tissues. The cytochrome p450 Ⅱ E1 immunohistochemical positive in colorectal carcinoma complicated with intestinal schistosomiasis group associated without gender,age,tumor location,lymph node metastasis,but with tissue differentiation degree and pathology classification. The stepwise regression method of logistic multiple factor analysis showed that the histological type was the only risk factors for the positive expression of P450 Ⅱ E1( OR = 11. 4,P = 0. 024). Conclusion CYP Ⅱ E1 expression is associated with colorectal cancer pathological tissue type. CYP II E1 plays a certain role in the pathogenesis of in colorectal carcinoma complicated with intestinal schistosomiasis
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